Antihyperglycemic Effect of Water Extracts from Pleurotus cornucopiae-Containing α-Glucosidase Inhibitor

Ja-Won Shin1   Sang-Min Bae1   Sang-Min Han1   Yun-Hae Lee2   Youn-Kyung Jeong2   Jeong-Hyun Ji2   Jong-Soo Lee1,*   

Abstract

Following preparation of water extracts of Pleurotus cornucopiae fruiting body-containing α-glucosidase inhibitor, their antihyperglycemic effects were examined using streptozotocin-induced diabetic Sprague-Dawley (SD)-rats. The water extracts from Pleurotus cornucopiae showed dosage-dependant antihyperglycemic effects on the streptozotocin-induced diabetic SD-rats after oral administration to 120 min on the short time test and 4 days on the long time test, respectively. The water extracts from Pleurotus cornucopiae fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min and 4 days in the SD-rat and streptozotocin-induced diabetic SD-rat.

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