Production of an Anti-dementia Butyrylcholinesterase Inhibitor from Non-pathogenic Wild Yeast, Saccharomyces cerevisiae WJSL 0113

Sang-Min Han1   Seon-Jeong Park1   Ji-Eun Jang1   Jong-Soo Lee1,*   

1Faculty of Biomedicine and Biotechnology, Paichai University, Daejeon 35345, Korea


In this study, screening of potent non-pathogenic wild yeast with high anti-dementia butyrylcholinesterase (BChE) inhibitory activity and production condition of a BChE inhibitor were described. Among 36 non-pathogenic wild yeasts, Saccharomyces cerevisiae WJSL 0113 showed the highest BChE inhibitory activity of 85.2%. The specific BChE inhibitor was maximally produced when S. cerevisiae WJSL 0113 was cultured at 30℃ for 48 h in a yeast extract-peptone-dextrose medium.

Figures & Tables

Fig. 1. Effect of cultural time on the butyrylcholinesterase inhibitory activities of Saccharomyces cerevisiae WJSL0113.