Korean Journal of Mycology (Kor. J. Mycol.)
Jun-Ho Kim*
Department of Fine Chemistry and New Materials, Sangji University, Wonju 220-702, Korea
Correspondence to jhokim@sangji.ac.kr
Korean Journal of Mycology (Kor J Mycol) September 30, 2014, 42(3):207-212.
https://doi.org/10.4489/KJM.2014.42.3.207
Received: July 17, 2014; Revised: August 28, 2014; Accepted: September 17, 2014
Published: September 30, 2014.
© The Korean Society of Mycology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
This study was conducted in order to investigate the physiological activities, including antioxidative, fibrinolytic, thrombin inhibitory, and α-glucosidase inhibitory activities of the water extract and solvent fractions isolated from Pholiota adiposa. The antioxidative activities of the water extract and water fraction were 57.57% and 48.27%, respectively. The fibrinolytic activity was strong only in the ethyl acetate fraction at 0.70 plasmin units/mL. The ethyl acetate fraction showed high thrombin inhibitory activity, and a-glucosidase inhibitory activity at 77.67% and 89.32%, respectively. The ethyl acetate fraction hydrolyzed both Aα and Bβ subunits of human fibrinogen, but did not show reactivity for the γ form of human fibrinogen. Fibrinolytic activity of the ethyl acetate fraction was not decreased by heating for 10 min at 100 oC.
Antioxidative activity, Fibrinolytic activity, Pholiota adiposa, Thrombin inhibitory activity