Korean Journal of Mycology (Kor. J. Mycol.)
Eun-Jung Kim 1, Kwan-Hee Yoo 2, Yang-Sup Kim 3, Soon-Ja Seok 4 and Jun-Ho Kim 5*
1Department of Biomedical Laboratory Science, Sangji University, Wonju 220-702, Korea
2Department of Life Science, Sangji University, Wonju 220-702, Korea
3Sejong Institute of Data Analysis Co Ltd., Suwon 433-270, Korea
4Agricultural Microbiology Division, National Academy of Agricultural Science, RDA, Wanju 565-851, Korea
5Department of Fine Chemistry and New Materials, Sangji University, Wonju 220-702, Korea
Correspondence to jhokim@sangji.ac.kr
Korean Journal of Mycology (Kor J Mycol) March 31, 2015, 43(1):40-46.
https://doi.org/10.4489/KJM.2015.43.1.40
Received: February 20, 2015; Revised: February 28, 2015; Accepted: March 5, 2015
Published: March 31, 2015.
© The Korean Society of Mycology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Physiological activities of solvent extracts of Sparassis crispa were investigated for fibrinolytic, thrombin inhibitory, anti-oxidative and anti-inflammatory activities. The fibrinolytic activity was the highest in ethyl acetate extract (2.03 plasmin units/ mL) followed by butanol extract (0.70 plasmin units/mL). The ethyl acetate extract exhibited the highest anti-oxidative activity as assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging rate with a value of 95.94%. The chloroform extract showed thrombin inhibitory activity up to 83.87%. The chloroform extract also showed the highest anti-inflammatory effects on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. These findings suggest that Sparassis crispa may be a useful material for development of drugs and functional foods.
Anti-inflammatory activity, Anti-oxidative activity, Fibrinolytic activity, Sparassis crispa, Thrombin inhibitory activity