Korean Journal of Mycology (Kor. J. Mycol.)
Ja-Won Shin 1, Sang-Min Bae 1, Sang-Min Han 1, Yun-Hae Lee 2, Jeong-Han Kim 2, Jeong-Hyun Ji 2 and Jong- Soo Lee 1*
1Department of Biomedicinal Science and Biotechnology, Paichai University, Daejeon 35345, Korea
2Mushroom Research Institute, Gyeonggi-do Agricultural Research & Extension Services, Gwangju 12805, Korea
Correspondence to biotech8@pcu.ac.kr
Korean Journal of Mycology (Kor J Mycol) September, 2015, 43(3):174-179.
https://doi.org/10.4489/KJM.2015.43.3.174
Received: July 10, 2015; Revised: September 7, 2015; Accepted: September 11, 2015
Published: September, 2015.
© The Korean Society of Mycology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
For development a new anti-diabetic compound from edible mushroom, antihyperglycemic α-glucosidase inhibitory activities of Pleurotus ostreatus, Pleurotus cornucopiae, Pleurotus salmoneostramineus, Pleurotus eryngii and Neolentinus lepideus were investigated on its water and ethanol extracts. α-Glucosidase inhibitory activity of Neolentinus lepideus fruiting body showed the highest at 86.3% in the 95% ethanol extracts and water extract from Pleurotus cornucopiae was also higher at 48.5% among water extracts. Therefore, Neolentinus lepideus which showed very high α-glucosidase inhibitory activity was selected as a new anti-diabetic agent-containing mushroom and the α-glucosidase inhibitor was maximally extracted when treated with 95% ethanol at 30 oC for 48 hr. The ethanol extracts from Neolentinus lepideus fruiting body showed dosage-dependent hypoglycemic action after administration to 120 min in the SD-rat and streptozotocin-induced diabetic SD-rat.
Antihyperglycemic effect, α-Glucosidase inhibitor, Neolentinus lepideus