Korean Journal of Mycology (Kor. J. Mycol.)
Do-Yeon Kim, Sang-Min Bae, Sang-Min Han and Jong-Soo Lee*
Department of Biomedicinal Science and Biotechnology, Paichai University, Daejeon 35345, Korea
Correspondence to biotech8@pcu.ac.kr
Korean Journal of Mycology (Kor J Mycol) December, 2016, 44(4):314-317.
https://doi.org/10.4489/KJM.2016.44.4.314
Received: December 5, 2016; Revised: December 16, 2016; Accepted: December 20, 2016
Published: December, 2016.
© The Korean Society of Mycology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
To develop a new anti-dementia acetylcholinesterase (AChE) inhibitor from edible mushrooms, AChE inhibitory activities were determined on water and ethanol extracts of various edible mushrooms from oriental medicine markets and agriculture markets. As a result, the 70% ethanol extract from Pholiota adiposa fruiting body had the highest AChE inhibitory activity of 30.6, and its water extract also had an AChE inhibitory activity of 23.8%. Therefore, we finally selected P. adiposa as a potent anti-dementia AChE inhibitor-containing mushroom. The AChE inhibitor of P. adiposa was maximally extracted when its fruiting body was treated with water for 3hr at 70 oC and 70% ethanol for 12 hr at 70 oC, respectively.
Acetylcholinesterase Inhibitor, Anti-dementia, Ethanol extract, Pholiota adiposa