Korean Journal of Mycology (Kor. J. Mycol.)
Sujeong Jang 1, Dong Hyeung Lee 2, Seong Hwan Kim 2, and Heonyong Park 1,*
1 Department of Molecular Biology & Institute of Nanosensor and Biotechnology, Dankook University,
Cheonan 31116, Korea
2 Department of Microbiology, Dankook University, Cheonan 31116, Korea
Correspondence to heonyong@dankook.ac.kr
Korean Journal of Mycology (Kor J Mycol) March, 2020, 48(1):1-13.
https://doi.org/10.4489/KJM.20200001
Accepted: March 27, 2020; Revised: March 26, 2020; Received: December 26, 2019
Published: March, 2020.
© 2020 THE KOREAN SOCIETY OF MYCOLOGY.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mushrooms have been extensively used as traditional medicines to treat cancer and inflammatory diseases. In this study, we examined whether Trametes cubensis extract (TCE) exerted beneficial effects on cardiovascular function. First, we demonstrated that TCE was non-cytotoxic and enhanced cell proliferation of bovine aortic endothelial cells (BAEC). Moreover, TCE induced cell migration and blocked lipopolysaccharide-induced adhesion of monocytes to BAEC. We performed a variety of cell signaling studies, showing that TCE activates p38 MAPK and generates reactive oxygen species (ROS). Our results showed that TCE-induced vascular functions were mediated by p38 MAPK, but not by ROS. These results provide insights into bio-medical applications of TCE as a preventive or therapeutic agent for treating cardiovascular diseases including atherosclerosis.
Cell migration, Endothelial cells, Heterotypic cell adhesion, p38 MAP kinase, Trametes cubensis