Korean Journal of Mycology (Kor. J. Mycol.)
Sang-Min Han, Seon-Jeong Park, Ji-Eun Jang, and Jong-Soo Lee *
Faculty of Biomedicine and Biotechnology, Paichai University, Daejeon 35345, Korea
Correspondence to biotech8@pcu.ac.kr
Korean Journal of Mycology (Kor J Mycol) June, 2021, 49(2):243-248.
https://doi.org/10.4489/KJM.20210021
Accepted: April 20, 2021; Revised: March 29, 2021; Received: February 10, 2021
Published: June, 2021.
© 2021 THE KOREAN SOCIETY OF MYCOLOGY.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
In this study, screening of potent non-pathogenic wild yeast with high anti-dementia butyrylcholinesterase (BChE) inhibitory activity and production condition of a BChE inhibitor were described. Among 36 non-pathogenic wild yeasts, Saccharomyces cerevisiae WJSL 0113 showed the highest BChE inhibitory activity of 85.2%. The specific BChE inhibitor was maximally produced when S. cerevisiae WJSL 0113 was cultured at 30℃ for 48 h in a yeast extract-peptone-dextrose medium.
Anti-dementia, Butyrylcholinesterase inhibitor, Saccharomyces cerevisiae WJSL 0113, Wild yeast