Physiological Activities of Water Extract and Solvent Fractions of an Edible Mushroom, Pholiota adiposa

Abstract

This study was conducted in order to investigate the physiological activities, including antioxidative, fibrinolytic, thrombin inhibitory, and α -glucosidase inhibitory activities of the water extract and solvent fractions isolated from Pholiota adiposa. The antioxidative activities of the water extract and water fraction were 57.57% and 48.27%, respectively. The fibrinolytic activity was strong only in the ethyl acetate fraction at 0.70 plasmin units/mL. The ethyl acetate fraction showed high thrombin inhibitory activity, and a-glucosidase inhibitory activity at 77.67% and 89.32%, respectively. The ethyl acetate fraction hydrolyzed both A α and B β subunits of human fibrinogen, but did not show reactivity for the γ form of human fibrinogen. Fibrinolytic activity of the ethyl acetate fraction was not decreased by heating for 10 min at 100ºC.

Acknowledgements

본 연구는 2013년도 상지대학교 교내연구비의 지원으로 이루어졌음을 밝히며 감사드립니다.

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