Screening of Potent Anti-dementia Acetylcholinesterase Inhibitor-containing Edible Mushroom Pholiota adiposa and the Optimal Extraction Conditions for the Acetylcholinesterase Inhibitor

Abstract

To develop a new anti-dementia acetylcholinesterase (AChE) inhibitor from edible mushrooms, AChE inhibitor activities were determined on water and ethanol extracts of various edible mushrooms from oriental medicine markets an agriculture markets. As a result, the 70% ethanol extract from Pholiota adiposa fruiting body had the highest AChE inhibitor activity of 30.6, and its water extract also had an AChE inhibitory activity of 23.8%. Therefore, we finally selected P. adiposa as potent anti-dementia AChE inhibitor-containing mushroom. The AChE inhibitor of P. a d i p o s a was maximally extracted when i fruiting body was treated with water for 3hr at 70^o C and 70% ethanol for 12 hr at 70^o C, respectively.

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