Screening of Anti-inflammatory Compound-producing Wild Yeasts and Their Microbiological Characteristics

Sang-Min  Bae1   Sang-Min  Han1   Jong-Soo  Lee1,*   

1Department of Biomedicinal Science and Biotechnology, Paichai University

Abstract

To screen for potent anti-inflammatory compound-producing yeasts, we evaluated nitric oxide production inhibitory activities in RAW 264.7 macrophage cells using cell-free extracts from 182 non-pathogenic yeasts. Rhodotorula graminis YJ36-1 and Meyerozyma guilliermondii YJ34-2 showed high inhibitory activities of 57.4% and 47.0%, respectively. The microbiological characteristics of these yeasts were investigated. Rhodotorula graminis YJ36-1 formed ascospores and pseudomycelium. This species grew well at 25°C in yeast extract- peptone-dextrose (YPD) medium, vitamin-free medium, and 5% NaCl-containing YPD medium. Meyerozyma guilliermondii YJ34-2 was an asporogenous yeast and did not form pseudomycelium. This strain also grew well at 30°C in YPD medium, vitamin-free medium, and 5% NaCl-containing YPD medium.

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